Oct 31 2020

Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment.

Davin Lee, Min Gu Jo, Seung Yeon Kim, Chang Geon Chung, Sung Bae Lee
Author Affiliations
Antioxidants (Basel, Switzerland)(Switzerland)

Advances in medicine and dietary standards over recent decades have remarkably increased human life expectancy. Unfortunately, the chance of developing age-related diseases, including neurodegenerative diseases (NDDs), increases with increased life expectancy. High metabolic demands of neurons are met by mitochondria, damage of which is thought to contribute to the development of many NDDs including Parkinson's disease (PD). Mitochondrial damage is closely associated with the abnormal production of reactive oxygen species (ROS), which are widely known to be toxic in various cellular environments, including NDD contexts. Thus, ways to prevent or slow mitochondrial dysfunction are needed for the treatment of these NDDs. In this review, we first detail how ROS are associated with mitochondrial dysfunction and review the cellular mechanisms, such as the mitochondrial quality control (MQC) system, by which neurons defend against both abnormal production of ROS and the subsequent accumulation of damaged mitochondria. We next highlight previous studies that link mitochondrial dysfunction with PD and how dietary antioxidants might provide reinforcement of the MQC system. Finally, we discuss how aging plays a role in mitochondrial dysfunction and PD before considering how healthy aging through proper diet and exercise may be salutary.

Keywords: Parkinson’s disease, dietary antioxidants, mitochondria, mitochondrial quality control, neurodegenerative disease, reactive oxygen species
Review, Journal Article
Antioxidants (Basel). ;9(11)

Suggested Articles

Nov 05 2020
Constipation and sleep behaviour disorder associate with processing speed and attention in males with Parkinson's disease over five years follow-up.
Scientific reports
Oct 31 2020
Gene and Cell-Based Therapies for Parkinson's Disease: Where Are We?
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Oct 29 2020
Variations in hospitalization rates across Parkinson's Foundation Centers of Excellence.
Parkinsonism & related disorders